Study tracker · Longevity
Epitalon
Updated 19 Oct 2026 · Peptilex evidence grade D (A = approved, large trials · D = mainly animal studies)
Rodent studies linked it to 20–40% longer mean lifespan and fewer tumors, and an independent group confirmed in 2025 that it lengthens telomeres in human cells. Registered human trials are the next step.
141PubMed papers
47Human studies
0Randomized trials
0Registered studies
0Ongoing / starting
0Phase 3+
Registered trials
From ClinicalTrials.gov, matched by name in the study title.
No registered trial yet on ClinicalTrials.gov – the research so far comes from published laboratory, animal and early human studies (below).
Selected publications
From PubMed. The full story – mechanism, all results, risks – is in the Epitalon profile of the book.
- 2026Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsRahman OF et al. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · PMID 41490200
- 2026LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphomaZhang Y et al. · Cell death & disease · PMID 42209466
- 2025Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising PropertiesAraj SK et al. · International journal of molecular sciences · PMID 40141333
- 2025The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic RetinopathyGatta M et al. · Stem cell reviews and reports · PMID 40493162
- 2025Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityAl-Dulaimi S et al. · Biogerontology · PMID 40908429
- 2025Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo developmentUllah S et al. · Life sciences · PMID 39788414
- 2024Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related ChangesKraskovskaya N et al. · International journal of molecular sciences · PMID 39518916
- 2022Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitroYue X et al. · Aging · PMID 35413689
