Study tracker · Metabolism · Mitochondria
MOTS-c
Updated 19 Oct 2026 · Peptilex evidence grade D (A = approved, large trials · D = mainly animal studies)
A peptide encoded in mitochondrial DNA, discovered in 2015. In mice it prevented diet-induced obesity and insulin resistance; a modified analogue (CB4211) completed a randomized phase 1a/1b trial with 88 participants.
264PubMed papers
152Human studies
4Randomized trials
2Registered studies
1Ongoing / starting
0Phase 3+
Registered trials
From ClinicalTrials.gov, matched by name in the study title.
| Study | Phase | Status | Participants | Start |
|---|---|---|---|---|
| Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation NCT07678073 · University of Gaziantep | – | Recruiting | 68 | 2026-03 |
| Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD NCT04027712 · University of Athens | Observational | Status unknown | 120 | 2014-01 |
1 further registry entry from a sponsor we could not verify is not listed.
Latest randomized trials & key papers
From PubMed. The full story – mechanism, all results, risks – is in the MOTS-c profile of the book.
- 2026Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic reviewAyubi N et al. · Physiology international · PMID 42640735
- 2025Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle ImmobilizationElhusseiny R et al. · Medicine and science in sports and exercise · PMID 40674654
- 2022Circulating levels of MOTS-c in patients with breast cancer treated with metforminCuyàs E et al. · Aging · PMID 36490309
- 2021Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humansvon Walden F et al. · Journal of applied physiology (Bethesda, Md. : 1985) · PMID 34351816
- 2021Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivorsDieli-Conwright CM et al. · Scientific reports · PMID 34413391
