Peptilex
Study tracker · Weight · Heart · Kidney

Semaglutide

Updated 19 Oct 2026 · Peptilex evidence grade A (A = approved, large trials · D = mainly animal studies)

Approved (Ozempic, Wegovy, Rybelsus), now also as a weight-loss tablet. Research has moved beyond the scale: 20% fewer heart attacks and strokes (SELECT), 24% fewer serious kidney events (FLOW) and MASH resolution in 63% vs 34% (ESSENCE).
5,707PubMed papers
3,251Human studies
311Randomized trials
477Registered studies
168Ongoing / starting
191Phase 3+

Registered trials

From ClinicalTrials.gov, matched by name in the study title.

StudyPhaseStatusParticipantsStart
STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
NCT06571383 · Novo Nordisk A/S
Phase 4Running5002024-09
Bariatric Surgery vs. Semaglutide vs. Tirzepatide
NCT06803888 · Ali Aminian
Phase 4Running1402025-01
A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma
NCT06792422 · Glostrup University Hospital, Copenhagen
Phase 4Recruiting1262025-01
GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH
NCT06003153 · Massachusetts General Hospital
Phase 4Recruiting1252024-03
Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity
NCT07136714 · Nordsjaellands Hospital
Phase 4Recruiting1162025-09
Semaglutide Treatment for Hyperglycaemia After Renal Transplantation
NCT05702931 · Copenhagen University Hospital, Rigshospitalet
Phase 4Recruiting1042024-09
The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes
NCT07272343 · Second Affiliated Hospital of Nanchang University
Phase 4Recruiting1002023-02
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
NCT06852391 · McMaster University
Phase 4Recruiting742025-06
Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization.
NCT07242534 · Fundacion Dexeus
Phase 4Recruiting622026-01
Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis
NCT07401992 · Hospital Universitario Dr. Jose E. Gonzalez
Phase 4Recruiting622026-01
Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults
NCT07513168 · Asian Institute Of Medical Sciences
Phase 4Recruiting602025-08
Semaglutide vs Sitagliptin
NCT05195944 · University Health Network, Toronto
Phase 4Running582022-10
Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
NCT05780905 · University of Washington
Phase 4Recruiting502024-01
A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity
NCT07728383 · Gila Therapeutics, Inc.
Phase 4Recruiting402026-06
Impact of Semaglutide on Tobacco Use and Related Health Behaviors
NCT06986993 · University of Oklahoma
Phase 4Recruiting402024-07
Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients
NCT06754163 · St Andrew's Healthcare
Phase 4Running202025-01
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 · Novo Nordisk A/S
Phase 3Recruiting2,5002026-05
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561 · Novo Nordisk A/S
Phase 3Running1,5002019-05
Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
NCT07284979 · Kailera
Phase 3Running1,2702025-12
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722 · Eli Lilly and Company
Phase 3Running1,2502024-02
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181 · Novo Nordisk A/S
Phase 3Running1,2052021-04
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
NCT07662213 · AstraZeneca
Phase 3Recruiting1,2002026-07
A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
NCT07668414 · Novo Nordisk A/S
Phase 3Recruiting6502026-09
A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity
NCT07285902 · Fujian Shengdi Pharmaceutical Co., Ltd.
Phase 3Running5722025-12
A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD）
NCT06884293 · Innovent Biologics (Suzhou) Co. Ltd.
Phase 3Running4792025-05

Showing 25 of 477 matching registered studies (ongoing first). See all on ClinicalTrials.gov.

Latest randomized trials & key papers

From PubMed. The full story – mechanism, all results, risks – is in the Semaglutide profile of the book.

Peptilex – The Honest GLP-1 Handbook, book cover

New: The Honest GLP-1 Handbook

Semaglutide, tirzepatide and the new pills, explained for adults over 50: what the trials show, a symptom-by-symptom side-effect troubleshooter, muscle and protein, and what happens when you stop. 172 pages.

Coming soon
Peptilex – The Peptide Encyclopedia, book cover

34 peptides. One book.

A science-based guide for beginners to 34 peptides: what each one does, the most exciting research results, and where it stands in 2026. Every profile: what it is, the most exciting results, key studies, risks and open questions.

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