Skin & beauty

Acetyl hexapeptide-8 (Argireline)

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Key studies from the book

Laboratory studies and a study in healthy women; wrinkle depth reduced by up to 30 percent after 30 days.
Blanes-Mira C et al. – International Journal of Cosmetic Science, 2002
Randomized, placebo-controlled, 60 adults, 4 weeks; overall anti-wrinkle efficacy 48.9 percent versus 0 percent on placebo.
Wang Y et al. – American Journal of Clinical Dermatology, 2013

All key studies, risks and open questions are in the book.

Publications by typePubMed, all years

All papers51

Human studies29

Animal studies only3

Randomized trials3

Meta-analyses & systematic reviews1

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 22

Phase 31

Other1

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

12016

2018

2020

2022

2024

2026

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

What it is, how it acts, the key studies, risks and open questions.

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ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
Argireline in Treatment of Periorbital Wrinkles NCT01381484Mahidol University	Phase 3	Completed	70	Mar 2009
A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm NCT00942851National Institute of Neurological Disorders and Stroke (NINDS)	Phase 1/2	Completed	24	Jul 2009
Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin NCT02597777University of California, Davis	–	Completed	14	Jan 2016
Acetyl Hexapeptide-8 for Blepharospasm NCT01750346National Institute of Neurological Disorders and Stroke (NINDS)	Phase 2	Stopped early	8	Nov 2012

PubMed · newest first