Healing · Gut

BPC-157

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Synthetic 15-amino-acid peptide, derived from a sequence found in a gastric protein
Main use or focus: Healing of tendons, ligaments, muscles and the gut

Key results

Research stageFrom lab to approval

LabTendon-cell studiesreached
Animal100+ animal studiesreached
Human3 small studies, 30 peoplereached
Randomized trialsRandomized trial starts 2027next step
Approvalnot yetnot yet

Source: Peptilex study tracker (weekly review)

100+

animal studies report faster healing of tendons, ligaments, muscle, bone and the gut lining

Animal studiesPreclinical research

people in the first systematic review of all human studies – symptom improvement in most participants

Systematic reviewSystematic review · 2026

2027

scheduled start of a randomized trial after rotator cuff surgery

Registered trialUniversity of Arkansas

Where it stands

More than 100 animal studies report faster healing of tendons, ligaments, muscle, bone and the gut lining. The first systematic review of all human studies (2026: 3 small studies, 30 people) found symptom improvement in most participants and no treatment-related side effects, and a randomized trial after rotator cuff surgery (University of Arkansas) is scheduled to start in 2027.

Go deeper

Full profile in the book

What it is, how it acts, the key studies, risks and open questions.

Peptilex – The Peptide Encyclopedia

34 peptides – from semaglutide to BPC-157 – in one book
An evidence grade (A–E) and the key studies for every peptide
Where each one stands in 2026 – US, EU and Switzerland

View on Amazon

Formats: Kindle · Paperback · Hardcover

Amazon store: amazon.com · Change store

Research at a glance

Publications by typePubMed, all years

All papers226

Human studies56

Animal studies only104

Randomized trials0

Meta-analyses & systematic reviews1

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 12

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

2017

2019

2021

2023

2025

12027

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials

ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery NCT07803250University of Arkansas	Phase 1	Starting soon	30	Jan 2027
PCO-02 - Safety and Pharmacokinetics Trial NCT02637284PharmaCotherapia d.o.o.	Phase 1	Status unknown	42	Oct 2015

1 further registry entry from a sponsor we could not verify is not listed.

Latest key papers

PubMed · newest first

2026
Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety
Systematic reviewPoolton JT et al. · Acta Orthopaedica BelgicaPMID 42885452
2026
Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury
Animal studyYıldırım AK et al. · Scientific ReportsPMID 42204242
2022
Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome
ReviewSikiric P et al. · World Journal of GastroenterologyPMID 35125818
2021
Pentadecapeptide BPC 157 counteracts L-NAME-induced catalepsy. BPC 157, L-NAME, L-arginine, NO-relation, in the suited rat acute and chronic models resembling 'positive-like' symptoms of schizophrenia
Animal studyZemba Cilic A et al. · Behavioural Brain ResearchPMID 32956773
2020
Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy
Animal studySikiric P et al. · Current Pharmaceutical DesignPMID 32329684
2019
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
ReviewGwyer D et al. · Cell and Tissue ResearchPMID 30915550
2018
BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing
ReviewSeiwerth S et al. · Current Pharmaceutical DesignPMID 29998800
2014
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
Lab studyChang CH et al. · MoleculesPMID 25415472

In the research news

19 Oct 20262 new
12 Oct 20261 new

Related peptides

DBTB-500 / thymosin beta-4 DKPV