Skin & beauty

Collagen peptides

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Hydrolyzed collagen: a mixture of small peptides from animal collagen
Main use or focus: Skin elasticity and hydration; joints; bones (oral supplements)

Key studies from the book

Meta-analysis of 26 randomized trials with 1,721 participants; better skin hydration and elasticity.
Pu SY et al. – Nutrients, 2023
Meta-analysis of 19 trials with 1,125 participants; better hydration, elasticity and wrinkles.
de Miranda RB et al. – International Journal of Dermatology, 2021

All key studies, risks and open questions are in the book.

Research at a glance

Publications by typePubMed, all years

All papers561

Human studies260

Animal studies only174

Randomized trials57

Meta-analyses & systematic reviews8

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 31

Other40

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

2016

22018

12020

82022

62024

42026

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

Full profile in the book

What it is, how it acts, the key studies, risks and open questions.

Peptilex – The Peptide Encyclopedia

34 peptides – from semaglutide to BPC-157 – in one book
An evidence grade (A–E) and the key studies for every peptide
Where each one stands in 2026 – US, EU and Switzerland

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Registered trials

ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis NCT04998188Istituto Ortopedico Rizzoli	–	Recruiting	204	Feb 2022
Collagen Peptides and Cellular Aging NCT07456449University of Vienna	–	Recruiting	125	Apr 2026
Evaluation of Oral Collagen Peptides on Skin Barrier Function in Women NCT07529249Centre de Pharmacologie Clinique Applique a la Dermatologie	–	Recruiting	75	Apr 2026
A Clinical Trial to Assess the Effect of AP-Brain Collagen Peptides on the Improvement of Attention, Focus, and Memory in Stressed But Otherwise Healthy Individuals NCT07572240Rousselot BVBA	–	Running	72	Jul 2026
Influence of Specific Collagen Peptides on Training-Induced Metabolic and Biomechanical Adaptations of Skeletal Muscle NCT06689761University of Vienna	–	Enrolling	60	Nov 2024
Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA) NCT05823727University of Arkansas	–	Recruiting	44	May 2026
Impact of Oral Supplementation With Bioactive Collagen Peptides and Other Functional Ingredients NCT07151482Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Observational	Starting soon	43	Sep 2025
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA) NCT00536302GELITA	Phase 2/3	Completed	30	Mar 2007
Collagen Peptide Supplementation and Physical Exercise in Older Adults NCT06240429University of Sao Paulo	–	Completed	160	Jan 2023
Efficacy of Bioactive Collagen Peptide Compared to Glucosamine and Chondroitin Sulphate in Grade I-III Knee Osteoarthritis NCT07746466Liaquat National Hospital & Medical College	–	Completed	150	Jun 2023

Show 15 moreShow fewer

Study	Phase	Status	Participants	Start
Efficacy Study of Oral Collagen Peptide on Skin Condition Improvement NCT06847035Shanghai Meifute Biotechnology Co., Ltd	–	Completed	90	Jul 2024
Collagen Peptide Supplementation and Lifelong Athletes NCT05751005Florida State University	–	Completed	86	Nov 2018
Oral Supplementation With Active Collagen Peptides and Skin Health Improvement NCT06321770Gala Servicios Clinicos S.L.	–	Completed	80	Mar 2024
Effect of Collagen Peptides, in Combination With Resistance Training, on Body Composition and Muscle Strength in Untrained Men NCT06061315University of Southern Denmark	–	Completed	80	Sep 2023
Hydrolyzed Collagen and Undenatured Collagen Type II in OA Knee NCT06229951Prince of Songkla University	–	Completed	68	Nov 2023
Clinical Effects of Two Oral Bioactive Collagen Peptides On Skin Properties and Aging Hallmarks NCT07302789Bionos Biotech S.L.	–	Completed	67	Feb 2025
Effect of Collagen Peptides on Skin Health: A Clinical Trial NCT07516756Collagen Research Institute	–	Completed	66	Aug 2024
Effectiveness of Hydrolyzed Collagen Peptide Injection for the Treatment of Collateral Ligament Pain NCT05971004Tiss'You srl	–	Completed	62	Apr 2022
Efficacy Testing of Collagen Peptide Drink NCT04996043TCI Co., Ltd.	–	Completed	60	May 2021
Assessment of Anti-aging Efficacy of Marine Collagen Peptides NCT06306105TCI Co., Ltd.	–	Completed	60	Mar 2024
Efficacy and Safety of AP Collagen Peptide on the Skin NCT05059197Amorepacific Corporation	–	Completed	54	Dec 2020
Hydrolyzed Collagen As A Host Modulation Agent in Non-Surgical Periodontal Treatment NCT07683741Hatice Yemenoglu	–	Completed	52	Feb 2025
Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides in Postmenopausal Women With Osteopenia NCT03999775Ioannis K. Triantafyllopoulos, MD,MSci,PhD	–	Completed	51	Jan 2017
Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage NCT05220371University of Vienna	–	Completed	50	Jan 2022
Effects of Hydrolyzed Collagen and Vitamin C on Explosive Performance NCT04437758PepsiCo Global R&D	–	Completed	50	Aug 2019

Showing 25 of 41 matching registered studies. See all on ClinicalTrials.gov.

Latest key papers

PubMed · newest first

2026
Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials
Meta-analysisNukaly HY et al. · Frontiers in MedicinePMID 41924746
2025
Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Human RCTLee E et al. · Journal of Microbiology and BiotechnologyPMID 40935395
2024
Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial
Human RCTVleminckx S et al. · Journal of Cosmetic DermatologyPMID 39143887
2024
Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study
Human RCTSeong SH et al. · Journal of Cosmetic DermatologyPMID 37822045
2023
Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults
Human RCTKviatkovsky SA et al. · Journal of the International Society of Sports NutritionPMID 37551682
2023
Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study
Human RCTLee M et al. · Food & FunctionPMID 36916504
2022
Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study
Human RCTKim J et al. · Journal of Medicinal FoodPMID 36516059
2021
The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Systematic reviewKhatri M et al. · Amino AcidsPMID 34491424

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