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Brain & mood

Dihexa

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Small modified peptide derived from angiotensin IV
Main use or focus: Memory, "brain regeneration", Alzheimer's

Research at a glance

Publications by typePubMed, all years

All papers26

Human studies11

Animal studies only6

Randomized trials1

Meta-analyses & systematic reviews1

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 11

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

12022

2024

2026

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

Full profile in the book

What it is, how it acts, the key studies, risks and open questions.

Peptilex – The Peptide Encyclopedia, book cover

Peptilex – The Peptide Encyclopedia

34 peptides – from semaglutide to BPC-157 – in one book
An evidence grade (A–E) and the key studies for every peptide
Where each one stands in 2026 – US, EU and Switzerland

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Registered trials

ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
A Study of the Absorption, Metabolism, and Excretion of [14C]-Fosgonimeton (ATH-1017) NCT05511558LeonaBio	Phase 1	Completed	8	Jul 2022

Latest key papers

PubMed · newest first

2024
Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease
Animal studyReda SM et al. · NeurotherapeuticsPMID 38599894
2023
Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia
Animal studyJohnston JL et al. · NeurotherapeuticsPMID 36538176
2022
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer's Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial
Human RCTPhase 1Hua X et al. · Journal of Alzheimer's DiseasePMID 35180125
2018
Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies
Systematic reviewHo JK et al. · Neuroscience and Biobehavioral ReviewsPMID 29733881

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