20–40%
longer mean lifespan, and fewer tumors, in rodent studies
Animal studiesRodent studies
Longevity
Epitalon
- Type
- Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
- Main use or focus
- Anti-aging; telomeres; sleep and melatonin
- Also known as
- Epithalon
Key results
- LabTelomeres longer in human cells (2025)reached
- Animal20–40% longer mean lifespan (rodents)reached
- HumanRegistered human trials are nextnext step
- Randomized trialsnot yetnot yet
- Approvalnot yetnot yet
Source: Peptilex study tracker (weekly review)
2025
independent confirmation that it lengthens telomeres in human cells
Lab studyHuman cell study
Where it stands
Rodent studies linked it to 20–40% longer mean lifespan and fewer tumors, and an independent group confirmed in 2025 that it lengthens telomeres in human cells. Registered human trials are the next step.
Go deeper
Full profile in the book
What it is, how it acts, the key studies, risks and open questions.
Peptilex – The Peptide Encyclopedia
- 34 peptides – from semaglutide to BPC-157 – in one book
- An evidence grade (A–E) and the key studies for every peptide
- Where each one stands in 2026 – US, EU and Switzerland
Research at a glance
All papers141
Human studies47
Animal studies only85
Randomized trials0
Meta-analyses & systematic reviews0
Source: PubMed and ClinicalTrials.gov via the Peptilex study database
Registered trials
ClinicalTrials.gov · name in study title · ongoing first
No registered trial yet on ClinicalTrials.gov.
Latest key papers
PubMed · newest first
- 2025
Lab studyAl-Dulaimi S et al. · BiogerontologyPMID 40908429
- 2025
Lab studyGatta M et al. · Stem Cell Reviews and ReportsPMID 40493162
- 2025
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
ReviewAraj SK et al. · International Journal of Molecular SciencesPMID 40141333
- 2025
Lab studyUllah S et al. · Life SciencesPMID 39788414
- 2022
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Lab studyYue X et al. · AgingPMID 35413689
- 2006
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
Animal studyKossoy G et al. · In VivoPMID 16634527
- 2005
Animal studyAnisimov VN et al. · Voprosy OnkologiiPMID 15909815
- 2002
Animal studyAnisimov VN et al. · Bulletin of Experimental Biology and MedicinePMID 12459848
In the research news
- 19 Oct 20263 new