Hormones & growth

Ipamorelin

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Synthetic GHRP (ghrelin receptor agonist), five amino acids
Main use or focus: Muscle, fat loss, sleep, recovery

Key studies from the book

Animal studies; the first selective growth hormone secretagogue, without a rise in ACTH or cortisol.
Raun K et al. – European Journal of Endocrinology, 1998

All key studies, risks and open questions are in the book.

Research at a glance

Publications by typePubMed, all years

All papers51

Human studies25

Animal studies only20

Randomized trials2

Meta-analyses & systematic reviews0

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 22

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

2016

2018

2020

2022

2024

2026

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

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What it is, how it acts, the key studies, risks and open questions.

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Registered trials

ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function NCT01280344Helsinn Therapeutics (U.S.), Inc	Phase 2	Completed	320	Apr 2011
Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus NCT00672074Helsinn Therapeutics (U.S.), Inc	Phase 2	Completed	117	Apr 2008

Latest key papers

PubMed · newest first

2024
The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism
Animal studyLu Z et al. · Physiology & BehaviorPMID 39043357
2014
Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients
Human RCTPhase 2Beck DE et al. · International Journal of Colorectal DiseasePMID 25331030
2009
Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus
Animal studyVenkova K et al. · The Journal of Pharmacology and Experimental TherapeuticsPMID 19289567
2000
The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats
Animal studySvensson J et al. · The Journal of EndocrinologyPMID 10828840
1999
Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers
Human RCTGobburu JV et al. · Pharmaceutical ResearchPMID 10496658
1999
Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats
Animal studyJohansen PB et al. · Growth Hormone & IGF ResearchPMID 10373343
1998
Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption
Animal studyJohansen PB et al. · Xenobiotica; the Fate of Foreign Compounds in Biological SystemsPMID 9879640
1998
Ipamorelin, the first selective growth hormone secretagogue
Animal studyRaun K et al. · European Journal of EndocrinologyPMID 9849822

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