Hormones & growth

Kisspeptin

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Natural peptide hormone (kisspeptin-54 and shorter fragments such as kisspeptin-10)
Main use or focus: Research: fertility treatment, reproductive hormone disorders, sexual desire

Key studies from the book

53 women in IVF; kisspeptin triggered egg maturation, clinical pregnancy rate 23 percent.
Jayasena CN et al. – Journal of Clinical Investigation, 2014
Phase 2, 60 women at high risk of hyperstimulation; egg maturation in 95 percent, no moderate or severe hyperstimulation, live birth in 45 percent of transfers.
Abbara A et al. – Journal of Clinical Endocrinology & Metabolism, 2015
Randomized, 32 women with low sexual desire; changed activity in the brain's sexual-processing network.
Thurston L et al. – JAMA Network Open, 2022

All key studies, risks and open questions are in the book.

Publications by typePubMed, all years

All papers3,331

Human studies1,229

Animal studies only1,671

Randomized trials33

Meta-analyses & systematic reviews19

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 17

Phase 25

Phase 31

Other9

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

22016

2018

2020

12022

12024

12026

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

What it is, how it acts, the key studies, risks and open questions.

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ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease NCT07224490Stephanie B. Seminara, MD	Phase 1	Recruiting	40	Mar 2026
Reproductive Hormones During Sustained Administration of Kisspeptin NCT02081924Imperial College London	–	Recruiting	76	Apr 2014
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys. NCT03286517Ghulam Nabi	Phase 3	Completed	30	Jun 2014
The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) Treatment NCT01667406Imperial College London	Phase 2	Completed	175	Jun 2012
Administration of Kisspeptin in Patients With Hyperprolactinemia NCT02956447Massachusetts General Hospital	Phase 2	Completed	36	Nov 2017
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism NCT04648969Stephanie B. Seminara, MD	Phase 2	Completed	18	May 2019
Kisspeptin Administration in the Adult NCT00914823Massachusetts General Hospital	Phase 1	Completed	256	Jun 2009
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling NCT01438073Massachusetts General Hospital	Phase 1	Completed	96	Sep 2011
Kisspeptin in the Evaluation of Delayed Puberty NCT01438034Massachusetts General Hospital	Phase 1	Completed	24	Jun 2013
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test NCT04958109Massachusetts General Hospital	Phase 1	Completed	16	Oct 2021

Show 9 moreShow fewer

Study	Phase	Status	Participants	Start
Dampening the Reproductive Axis With Continuous Kisspeptin NCT05971849Stephanie B. Seminara, MD	Phase 1	Completed	8	Oct 2023
Kisspeptin/GPR54 Pathway and Early Puberty NCT04012632Shenzhen Center for Disease Control and Prevention	Observational	Completed	628	Sep 2016
Detection of Kisspeptins and miRNAs in Patients With Non-viable Pregnancy NCT03877939Vida Recoletas Sevilla	Observational	Completed	433	Sep 2019
Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells NCT02877992Vida Recoletas Sevilla	–	Completed	236	Jan 2014
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not? NCT03940495ShangHai Ji Ai Genetics & IVF Institute	Observational	Completed	182	May 2019
Serum Kisspeptin Levels in Infertile Women NCT03018314Bakirkoy Dr. Sadi Konuk Research and Training Hospital	Observational	Completed	90	Jun 2016
Kisspeptin Levels in Early Pregnancy NCT04371991Semra Yuksel	Observational	Completed	88	Jan 2019
Association of Kisspeptin Levels With Insulin Secretion in Diabetes Mellitus NCT01956851Ganga Care Hospital, Nagpur	Observational	Completed	55	Sep 2013
A Prospective Cohort Study on the Serum Kisspeptin Levels Throughout Pregnancy in PCOS NCT06545994Fudan University	Observational	Status unknown	180	Jun 2024

Showing 19 of 22 matching registered studies. See all on ClinicalTrials.gov.

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