Peptilex
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The book

Healing & recovery

KPV

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work
Type
Tripeptide (lysine–proline–valine), the end fragment of alpha-MSH
Main use or focus
Inflammatory bowel disease, skin inflammation

Key studies from the book

  • Cells and mouse colitis; KPV taken up through the PepT1 transporter reduced intestinal inflammation.

    Dalmasso G et al. – Gastroenterology, 2008
  • Two mouse models of colitis; faster recovery and less inflammation.

    Kannengiesser K et al. – Inflammatory Bowel Diseases, 2008

All key studies, risks and open questions are in the book.

Research at a glance

Publications by typePubMed, all years
All papers52
Human studies28
Animal studies only14
Randomized trials0
Meta-analyses & systematic reviews0

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

Full profile in the book

What it is, how it acts, the key studies, risks and open questions.

Peptilex – The Peptide Encyclopedia, book cover

Peptilex – The Peptide Encyclopedia

  • 34 peptides – from semaglutide to BPC-157 – in one book
  • An evidence grade (A–E) and the key studies for every peptide
  • Where each one stands in 2026 – US, EU and Switzerland

Formats: Kindle · Paperback · Hardcover

Amazon store: amazon.com · Change store

Registered trials

ClinicalTrials.gov · name in study title · ongoing first

No registered trial yet on ClinicalTrials.gov.

Latest key papers

PubMed · newest first

  1. 2024

    KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy

    Human studyZhang L et al. · Advanced Healthcare MaterialsPMID 39252648

  2. 2022

    A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

    Animal studyZhao Y et al. · Acta BiomaterialiaPMID 35245681

  3. 2021
  4. 2008

    Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

    Animal studyKannengiesser K et al. · Inflammatory Bowel DiseasesPMID 18092346

  5. 2003

    Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides

    Animal studyGetting SJ et al. · The Journal of Pharmacology and Experimental TherapeuticsPMID 12750433

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