Brain & mood

Selank

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Synthetic seven-amino-acid analogue of tuftsin
Main use or focus: Anxiety (Russia); calm focus

Key studies from the book

62 patients with generalized anxiety disorder or neurasthenia; anxiety reduction comparable to a benzodiazepine, with fewer sedative effects.
Zozulya AA et al. – Zhurnal Nevrologii i Psikhiatrii, 2008
Review of Selank's molecular actions.
Vyunova TV et al. – Protein and Peptide Letters, 2018

All key studies, risks and open questions are in the book.

Research at a glance

Publications by typePubMed, all years

All papers68

Human studies15

Animal studies only49

Randomized trials2

Meta-analyses & systematic reviews0

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

Full profile in the book

What it is, how it acts, the key studies, risks and open questions.

Peptilex – The Peptide Encyclopedia

34 peptides – from semaglutide to BPC-157 – in one book
An evidence grade (A–E) and the key studies for every peptide
Where each one stands in 2026 – US, EU and Switzerland

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Registered trials

ClinicalTrials.gov · name in study title · ongoing first

No registered trial yet on ClinicalTrials.gov.

Latest key papers

PubMed · newest first

2022
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats
Animal studyKonstantinopolsky MA et al. · Bulletin of Experimental Biology and MedicinePMID 36322304
2021
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank
Human studyDoyno CR et al. · Journal of Clinical PharmacologyPMID 34396551
2021
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress
Animal studyLeonidovna YA et al. · Current Reviews in Clinical and Experimental PharmacologyPMID 32621722
2020
Functional Connectomic Approach to Studying Selank and Semax Effects
Human studyPanikratova YR et al. · Doklady Biological SciencesPMID 32342318
2019
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress
Animal studyFomenko EV et al. · Bulletin of Experimental Biology and MedicinePMID 31243679
2018
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
Animal studyVyunova TV et al. · Protein and Peptide LettersPMID 30255741
2017
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
Animal studyKasian A et al. · Behavioural NeurologyPMID 28280289
2016
[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]
Animal studyVasil'eva EV et al. · Eksperimental'naia I Klinicheskaia FarmakologiiaPMID 29787664

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