Bone

Teriparatide & abaloparatide

Peptilex evidence grade ABCDEUpdated 19 Oct 2026 How grades work

Type: Analogues of parathyroid hormone (PTH) and PTH-related protein
Main use or focus: Osteoporosis with high fracture risk
Also known as: Forteo, Tymlos

Key studies from the book

1,637 postmenopausal women, median 21 months; about 65 percent fewer new vertebral fractures with teriparatide.
Fracture Prevention Trial – New England Journal of Medicine, 2001
2,463 postmenopausal women, 18 months; new vertebral fractures in 0.58 percent with abaloparatide versus 4.22 percent on placebo.
ACTIVE – JAMA, 2016

All key studies, risks and open questions are in the book.

Research at a glance

Publications by typePubMed, all years

All papers3,218

Human studies2,216

Animal studies only211

Randomized trials276

Meta-analyses & systematic reviews168

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Registered trials by phaseClinicalTrials.gov · name in study title

ongoing / startingcompleted / other

Phase 110

Phase 223

Phase 328

Phase 434

Other17

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Trial starts per yearClinicalTrials.gov · by start date (planned starts included)

22016

32018

42020

12022

2024

2026

Source: PubMed and ClinicalTrials.gov via the Peptilex study database

Go deeper

Full profile in the book

What it is, how it acts, the key studies, risks and open questions.

Peptilex – The Peptide Encyclopedia

34 peptides – from semaglutide to BPC-157 – in one book
An evidence grade (A–E) and the key studies for every peptide
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Registered trials

ClinicalTrials.gov · name in study title · ongoing first

Study	Phase	Status	Participants	Start
Fracture Recovery for Returning to Duty (Teriparatide STRONG) NCT04589819University of South Carolina	Phase 4	Enrolling	183	Dec 2022
Abaloparatide Added to Ongoing Denosumab vs Continued Denosumab Alone NCT04467983Hospital for Special Surgery, New York	Phase 4	Running	70	Feb 2021
Abaloparatide vs. Placebo in Post-Menopausal Women and Abaloparatide in Men Receiving Initial Spinal Fusion Surgery NCT03841058Hospital for Special Surgery, New York	Phase 2	Running	96	Aug 2019
Preoperative Teriparatide Use on Insertional Torque of Pedicle Screws for Lumbar Fusion Surgery NCT03770338The University of Hong Kong	–	Running	192	Mar 2019
Effects of Teriparatide (PTH) on Bone in Men and Women With Osteoporosis NCT01155232University Health Network, Toronto	Observational	Running	100	Nov 2004
Comparation of Treatment Strategies for OVF: Teriparatide Injection and PVP NCT03692143Nanfang Hospital, Southern Medical University	Observational	Running	90	Jan 2017
Teriparatide (PTH) and Bone Strength in Postmenopausal Women NCT01155245University Health Network, Toronto	Observational	Running	60	Jun 2008
MicroRNA and Markers and Therapeutic Response to Romosozumab and Abaloparatide in Postmenopausal Osteoporosis NCT07616401Istituto Auxologico Italiano	–	Recruiting	42	Aug 2025
To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of Fracture NCT06898060Qilu Pharmaceutical Co., Ltd.	Phase 3	Starting soon	282	Jun 2025
Chronotherapeutic Optimization of Teriparatide Administration in Postmenopausal Osteoporosis NCT06951776Peking University Third Hospital	–	Starting soon	28	May 2025

Show 15 moreShow fewer

Study	Phase	Status	Participants	Start
2-Year Therapy With Teriparatide vs 1-yr Therapy Followed by 1-Year of Raloxifene or Calcium/Vit D in Severe Postmenopausal Osteoporosis NCT00191425Eli Lilly and Company	Phase 4	Completed	810	Aug 2002
Sequential Use of Teriparatide and Raloxifene HCl in the Treatment of Postmenopausal Women With Osteoporosis NCT00035256Eli Lilly and Company	Phase 4	Completed	330	Oct 2001
OPTAMISE: Clinical Effectiveness of Teriparatide After Alendronate or Risedronate Therapy in Osteoporotic Postmenopausal Women NCT00130403Sanofi	Phase 4	Completed	290	Mar 2004
The Forteo Alendronate Comparator Trial NCT02416271Eli Lilly and Company	Phase 4	Completed	203	Apr 2001
Effects of Teriparatide in Postmenopausal Women With Osteoporosis NCT00079924Eli Lilly and Company	Phase 4	Completed	200	Nov 2004
Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta NCT00131469Oregon Health and Science University	Phase 4	Completed	79	Jun 2005
Denosumab and Teriparatide Study (DATA-HD and DATA-EX) NCT02176382Massachusetts General Hospital	Phase 4	Completed	76	Aug 2014
Teriparatide and Strontium Ranelate Head-To-Head Comparison Trial NCT00239629Eli Lilly and Company	Phase 4	Completed	73	Sep 2005
Effects of Teriparatide or Denosumab on Bone in Postmenopausal Women With Osteoporosis NCT01753856Eli Lilly and Company	Phase 4	Completed	69	Jan 2013
Effects of Teriparatide or Zoledronic Acid Treatment on Bone in Postmenopausal Osteoporotic Women NCT00927186Eli Lilly and Company	Phase 4	Completed	69	Jul 2009
Abaloparatide Before Total Knee Arthroplasty NCT04167163University of Wisconsin, Madison	Phase 4	Completed	58	Jan 2020
Bone Marker Changes With Teriparatide/Postmenopausal Osteoporosis NCT00532545Eli Lilly and Company	Phase 4	Completed	45	Apr 2003
Does Teriparatide (rhPTH 1-34) Promote Fracture Healing in Proximal Humeral Fractures? NCT01105832University Hospital, Linkoeping	Phase 4	Completed	40	Apr 2010
Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion NCT01292252Shane Burch	Phase 4	Completed	36	Aug 2011
A Study Using Imaging Technology to Measure Changes in Bone Structure After Treatment With Teriparatide NCT00557310Eli Lilly and Company	Phase 4	Completed	35	Nov 2007

Showing 25 of 112 matching registered studies. See all on ClinicalTrials.gov.

Latest key papers

PubMed · newest first

2026
Teriparatide Plus Zoledronic Acid for Osteogenesis Imperfecta: A Randomized Clinical Trial
Human RCTHald JD et al. · JAMAPMID 42133304
2026
Effects of romosozumab on bone strength around a pedicle screw as evaluated by biomechanical computed tomography-based virtual stress tests in postmenopausal women
Human RCTPhase 3Keaveny TM et al. · The Spine JournalPMID 42051047
2025
A randomized controlled trial of teriparatide for accelerating bone union and improving clinical outcomes in patients with pertrochanteric fracture fixation
Human RCTTanavalee C et al. · Scientific ReportsPMID 40461584
2025
Probability of achieving bone mineral density treatment targets with abaloparatide and teriparatide
Human RCTCosman F et al. · Journal of Bone and Mineral ResearchPMID 40214193
2025
Perioperative teriparatide for preventing proximal junctional kyphosis and failure in patients with osteoporosis after adult thoracolumbar spinal deformity surgery: a prospective randomized controlled trial
Human RCTPark JH et al. · Osteoporosis InternationalPMID 40100350
2025
PTH1 receptor agonists for fracture risk: a systematic review and network meta-analysis
Meta-analysisBeaudart C et al. · Osteoporosis InternationalPMID 40047881
2024
Efficacy and safety of teriparatide vs. bisphosphonates and denosumab vs. bisphosphonates in osteoporosis not previously treated with bisphosphonates: a systematic review and meta-analysis of randomized controlled trials
Meta-analysisLi M et al. · Archives of OsteoporosisPMID 39312040
2024
Conservative Treatments in the Management of Acute Painful Vertebral Compression Fractures: A Systematic Review and Network Meta-Analysis
Meta-analysisAlimy AR et al. · JAMA Network OpenPMID 39240564

In the research news

19 Oct 20261 new
12 Oct 20262 new

Key studies from the book

Research at a glance

Full profile in the book

Peptilex – The Peptide Encyclopedia

Registered trials

Latest key papers

In the research news

Related peptides